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Protonix.

Protonix is a proton pump inhibitor.
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Indications for use of protonix or protonix generic.
- gastric ulcer or duodenal ulcer in the acute phase, including associated with NSAID, or -refractory to histamine blocker therapy H2-receptor,
- moderate and severe forms of gastroesophageal reflux disease,
- Zollinger - Ellison syndrome,
- H. pylori eradication combination therapy for patients with peptic ulcer disease to reduce the frequency of relapses.

Dosage of protonix or protonix generic.
Protonix is taken inside before breakfast and / or pre-dinner or during a meal, without chewing or breaking the tablet and drank the liquid.
Treatment of gastric ulcers and duodenal ulcers and gastroesophageal reflux disease - 40 mg of pantoprazole per day, with erosive and ulcerative forms of reflux esophagitis is permissible increase to 80 mg of Protonix daily.
Eradication of Helicobacter pylori - only in the combined therapy (Protonix monotherapy for Helicobacter pylori eradication is not allowed) in the treatment of Helicobacter-associated gastric or duodenal ulcers - Protonix 40 mg plus 1000 mg of amoxicillin plus 500 mg clarithromycin, all 2 times a day. Instead of amoxicillin may be appointed metronidazole 500 mg. Course duration - one or two weeks.

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Contraindications.
Hypersensitivity to protonix or protonix generic, hepatitis and cirrhosis of the liver, accompanied by severe hepatic insufficiency.
Liver dysfunction, childhood, pregnancy, lactation.
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Pharmacological action.
Protonix has antibacterial activity against Helicobacter pylori.
The therapeutic effect after a single dose of protonix or protonix generic occurs rapidly and persists for 24 hours. Protonix provides rapid reduction of symptoms and healing of duodenal ulcer. When administered at a dose of 40 mg of pH> 3 retained more than 19 hours.
After 2 weeks of treatment (40 mg daily) the complete healing of duodenal ulcers observed in 89%. After 4 weeks of treatment (40 mg) in 88% of patients experience complete healing of gastric ulcers. The frequency of recurrence of peptic ulcers after treatment was 55%.
Within 4 weeks of treatment at a dose of 40 mg per day provides a complete remission in 82% of patients with GERD stage II-III (according to Savary-Miller), 8 weeks - at 92%. Complete endoscopic remission in 57% of children 6-13 years with GERD stages I-II (by Vandeplas) is reached after 4 weeks of therapy at a dose of 20 mg per day. During the 4-8 weeks of treatment the level of gastrin in plasma increased 1.5 times.
Protonix or protonix generic is rapidly and completely absorbed after oral administration. Absolute bioavailability 70-80%, average - 77%. Cmax is achieved in 2-4 hours (on average - over 2.7 hours). Plasma protein binding is 98%. T ½ - 0,9-1,9 hours, volume of distribution - 0.15 L / kg, Cl - 0,1 l / h / kg.

How to use of Protonix during pregnancy and breastfeeding.
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Acceptance of Protonix for the treatment of GERD during the first trimester of pregnancy increases the risk of having a baby with heart defects in more than two times (GI & Hepatology News, August 2010). Acceptance of Protonix during pregnancy is possible only on strict indications, when the benefits to the mother outweighs the potential risk to the fetus. At the time of treatment should stop breastfeeding. We have the lowest protonix price.

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Side effects of protonix.
The digestive system: diarrhea, rarely - dry mouth, increased appetite, nausea, belching, vomiting, flatulence, abdominal pain, constipation.
Nervous system and sense organs: headache, rarely - fatigue, dizziness, drowsiness, insomnia, and in some cases - anxiety, depression.
Urogenital: in rare cases - hematuria, edema.
Allergic reactions: seldom - a rash, hives, itching.

The interaction of Protonix with other drugs.
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Protonix or protonix generic can reduce absorption of ketoconazole . Compatible with drugs metabolized by the participation of cytochrome P450 enzyme system: phenazepam, diazepam, digoxin, theophylline, carbamazepine, diclofenac, naproxen, piroxicam, phenytoin, warfarin, nifedipine, metoprolol, ethanol. Not affect the effectiveness of hormonal contraceptives.

Product form.
Pills protonix 40 mg (Normal Dosage),
protonix 20 mg ( Low Dosage).

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